Regenerative Approaches For Joint Health: Prolotherapy, short for proliferative therapy, is a minimally invasive, natural treatment that can work on any joint. The regenerative injection therapy, which relieves pain by strengthening ligaments and tendons supporting the joint, involves the injection of a dextrose solution directly into the affected area. The body’s inflammation response kicks in, resulting in production of collagen and regrowth of new fibers in ligaments and tendons.